Folderol http://folderol.org/ Wed, 22 Sep 2021 22:59:52 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 http://folderol.org/wp-content/uploads/2021/07/icon-1-150x150.png Folderol http://folderol.org/ 32 32 Governor Newsom signs legislation strengthening access to reproductive health care and protecting patients and providers, lifts new reproductive freedom advisory group http://folderol.org/governor-newsom-signs-legislation-strengthening-access-to-reproductive-health-care-and-protecting-patients-and-providers-lifts-new-reproductive-freedom-advisory-group/ http://folderol.org/governor-newsom-signs-legislation-strengthening-access-to-reproductive-health-care-and-protecting-patients-and-providers-lifts-new-reproductive-freedom-advisory-group/#respond Wed, 22 Sep 2021 21:52:16 +0000 http://folderol.org/governor-newsom-signs-legislation-strengthening-access-to-reproductive-health-care-and-protecting-patients-and-providers-lifts-new-reproductive-freedom-advisory-group/

AB 1356 strengthens protections, both online and in healthcare settings, for patients seeking reproductive health services

AB 1184 protects the privacy rights of people receiving sensitive health care services, such as reproductive health care and gender-affirming care

Governor lifts California Future of Abortion Council convened by reproductive rights and justice organizations to protect and expand access to reproductive health care in state

SACRAMENTO – In the face of unprecedented attacks on women’s health care and reproductive rights across the country, Governor Gavin Newsom today announced the administration’s participation in a new advisory group, the California Future of Abortion Council , to advance state leadership in matters of reproductive freedom and signed legislation strengthen the state’s commitment to ensure access to essential reproductive and sexual health services. The legislation will protect the privacy of patients seeking sensitive health services, including reproductive health care, and create new safeguards to protect patients and providers from harassment.

“California has been a leader in protecting access to sexual and reproductive rights, but as we have seen recently with unprecedented attacks on these rights, we can and must do more,” said the Governor Newsom. “I applaud the creation of the California Future of Abortion Council and look forward to its important work in advancing our state’s leadership on this vital issue. I am proud today to sign these two bills that demonstrate our commitment to further strengthen and protect access to reproductive health services in California.

AB 1356 by Assembly Member Rebecca Bauer-Kahan (D-Orinda) increases sentences for current crimes under the California Freedom of Access to Clinic Act and updates online privacy laws and training peace officers related to reproduction rights offenses. It creates new offenses resulting from recording or photographing patients or providers within 100 feet of the entrance to a reproductive health service facility.

AB 1184 by Assembly Member David Chiu (D-San Francisco) protects the privacy rights of people receiving sensitive health care services, including reproductive health care and gender care, by ensuring that patient information remains confidential if they are not the primary policyholder of their health insurance.

The action comes in the wake of attacks on sexual health care and reproductive rights across the country, including the U.S. Supreme Court’s failure to block Texas abortion ban after six weeks. California is a national leader in reproductive and sexual health protection and rights, and Governor Newsom’s actions today make it clear that the state will remain a safe haven for all Californians and those coming from across the country. out of state who seek reproductive health services here. The Administration’s participation in the new “California Future of Abortion Council” – launched by Planned Parenthood Affiliates of California (PPAC), NARAL-Pro Choice CA, Black Women for Wellness, ACCESS Reproductive Justice and National Health Law Program (NHelp) – work collaboratively with researchers, advocates, policy makers, providers, patients and key constituents to identify potential challenges that currently exist or may arise, and recommend solutions that will continue the state’s leadership in freedom reproductive.

In 2019, Governor Newsom signed a proclamation on reproductive freedom, reaffirming California’s commitment to protect women’s reproductive choices. The Governor has advanced investments to expand access to reproductive and sexual health care and signed several bills protecting reproductive freedom, including SB 374 earlier this year and SB 24 and AB 1264 in 2019.

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DNA methylation influences the replication and organization of the genome http://folderol.org/dna-methylation-influences-the-replication-and-organization-of-the-genome/ http://folderol.org/dna-methylation-influences-the-replication-and-organization-of-the-genome/#respond Wed, 22 Sep 2021 19:52:50 +0000 http://folderol.org/dna-methylation-influences-the-replication-and-organization-of-the-genome/

MMost cancer cells have much less methylated genomes than those of normal cells, but whether this loss of methylation, an epigenetic process, has functional significance for cells has long been an unanswered question. Now researchers show that cells that loss of DNA methylation throughout the genome alters the timing of DNA replication and alters the shape of 3-D compartmentalization of DNA, which helps orient the gene expression.

The study, published on September 21 in Cell reports, is “an elegant dissection of the impact of DNA methylation on the organization of the 3-D genome,” says Emma Bell, a bioinformatician at the Pricess Margaret Cancer Center in Toronto who was not involved in the work. “It’s really important to show how aberrant DNA methylation, which is a common cancer artefact, impacts higher order genome organization and DNA replication.”

For about 25 years, Susan Clark and her group at the Garvan Institute of Medical Research in Australia have been interested in how epigenetics are involved in cancer. As most cancer cells lose DNA methylation throughout the genome, it was surprising how little was known about the overall consequences of hypomethylation, Clark explains in an email to The scientist.

Methylation of the genome is a kind of fingerprint for a cell, and cell identity is also guided by the organization of the genome into 3-D compartments that help determine which genes are expressed. Clark and his colleagues hypothesized that DNA methylation plays a role in maintaining this genomic architecture and, in the new study, used colorectal cancer cells to investigate this hypothesis.

The researchers started with two versions of the same cells: a normal cancerous cell line and one with knockouts of two DNA methyltransferase enzymes, which mimic the methylation pattern of one strand of DNA onto generated daughter DNA strands. during replication. Cells lacking DNA methyltransferases exhibited reduced methylation levels genome-wide. Then, in individual cells of the two cell lines, they mapped DNA replication throughout the genome and studied the 3-D organization of the genomes.

The team found that hypomethylation caused a change in the replication schedule – that is, how sooner or later a region was copied during replication. Most of these changes were moderate: regions replicated slightly earlier or later in genomes that lacked methylation. But more than three percent of the hypomethylated genomes were replicated much earlier or later than in cells with intact DNA methyltransferases.

It is “surprising that they could have seen these differences in the timing of replication when they got rid of methyltransferases,” says Christine Cucinotta, who studies chromatin architecture at the Fred Hutchinson Cancer Research Center in Seattle and does did not participate in the work. The replication schedule, she adds, is “generally quite robust outside of transitions in cell fate.”

These changes in the replication schedule also appeared to affect the 3-D organization of genomic regions, particularly in the so-called partially methylated domains, which are places that in ordinary cancer cells have lower levels of methylation of the genome. ‘DNA. This DNA architecture, in turn, plays a role in gene expression. For example, when DNA replication shifted earlier in hypomethylated cells, there was a shift to 3-D structures indicating more active gene expression, which the researchers also observed. They determined that the loss of precision in replication and associated changes in 3-D compartmentalization and gene expression particularly affected genes linked to cancer.

“These results highlight the role of epigenetics in cancer progression which may help explain how cancers can become more heterogeneous with each cell division,” writes Clark.

Clark’s group also found evidence suggesting that the cell may reduce the impact of reduced methylation to some extent. In regions of hypomethylated cells where replication was delayed, the team saw an increase in DNA bands in which histone H3 had been altered by both chromatin repressive markings and those associated with DNA. more accessible for transcription. This new double layer of regulation can “suppress the overall disruption of gene transcription across compartments,” explains Clark. The scientist.

This work confirms the proposed link between DNA methylation, histone methylation, changes in transcription and replication schedule, explains Susan Gasser, molecular biologist affiliated with the University of Basel and the Friedrich Miescher Institute of biomedical research in Switzerland which did not participate in the study. “The important thing is not to say that DNA methylation is the trigger for the whole cascade,” she adds. “I think we see that there is a balance between these four things, and that there are regions of the genome that are hypersensitive to. . . these fluctuations.

A next step would be “a comparison between healthy cells, precancerous cells and cancer cells,” Bell said. The scientist. “What we’ve portrayed here is a picture of cancer and aberrant DNA methylation, but it doesn’t happen all at once. I would like to see what happens in DNA methylation, 3D genome organization and DNA replication timing during the process of oncogenesis.


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Buying a gun in the United States is as easy as shopping in India http://folderol.org/buying-a-gun-in-the-united-states-is-as-easy-as-shopping-in-india/ http://folderol.org/buying-a-gun-in-the-united-states-is-as-easy-as-shopping-in-india/#respond Wed, 22 Sep 2021 01:11:33 +0000 http://folderol.org/buying-a-gun-in-the-united-states-is-as-easy-as-shopping-in-india/

Today we’re going to tell you the story of American gun culture. The US Constitution gives all of its citizens the right to own a firearm. Guns are as easy to find in stores in America as you get fruits and vegetables in stores in India. The result is that over the past 50 years, more than 1.4 million people have died from gun violence in America.

The gun culture in America dates back to when the British government was there. At that time, there was no police or permanent security force and people had to protect themselves and their families, so they had the right to bear arms.

By the 19th century America had realized that gun culture would never allow for the establishment of peace, however, due to pressure from Gun Lobby and some politicians, no strict laws could ever be passed against it. she. And today in America an average of 100 people die every day because of it.

The history of gun culture in America is as old as the American Constitution.

In 1791, the Second Amendment to the United States Constitution came into effect, and under it, American citizens were granted the right to bear arms. But this right also had a price. Millions of people have lost their lives to America’s gun culture for decades, and the burden of those deaths has increased over time on the US Parliament.

Even after 230 years, America has not been able to change this law today. The Parliament of America, which people expect a strict law to be passed on this, there are many such stores a short distance from this Parliament where you can easily buy modern weapons. .

According to a 2019 report, there are 63,000 licensed arms dealers in the United States, who have sold weapons worth Rs 83,000 crore to American citizens. This is much more than India’s health budget this year. (Figures for arms sales for 2018).

America may declare itself a champion of democracy in the world, but the truth is that it could neither win the war on terrorism by sending its armies to other countries, nor defeat armed terror in its own country.

Over the past 230 years, America has not been able to eradicate gun culture because the former president himself was influenced by it. We have some photos for you, in which you can see former US presidents with guns. For example, former US President Theodore Roosevelt loved to be photographed with a gun. He was President of the United States from 1901 to 1909. Likewise, you can also see photos of Franklin D Roosevelt, Jimmy Carter, George Bush Sr. and George W Bush. All of these leaders have glorified gun culture in the past when they were president.

This too when gun culture was the main reason behind the assassinations of four former US presidents. 16th US President Abraham Lincoln and 20th President James A Garfield were murdered with guns.

American gun culture statistics

Between 2002 and 2011, an average of 31 people were killed in terrorist attacks in the United States each year. While an average of 11,000 people have lost their lives each year due to gun culture. Although America has declared a decisive fight against terrorism, it has never been able to do anything to stop gun culture.

  1. 58% of Americans have been confronted with Gun Terror
  2. Every day, an average of 100 people are killed in armed violence.
  3. 3 million children fight mass shooting or gun culture every year
  4. In 2018, there were 27 major mass shooting incidents in America.
  5. America’s total population is 33 and a half million, but the people there have around 400 million guns.

While India is second in this case with 70 million weapons and China third with 50 million weapons. The United States has 120 guns per 100 inhabitants, while Yemen comes in second, where there are 52 guns per 100 inhabitants. This is also the case when about 60% of Americans want tough laws to end gun culture.

America is the only country in the world where it is very easy for people to kill themselves because of gun culture. In 2019, around 24,000 people killed themselves by shooting themselves.

It is not difficult for Americans to buy a gun. All it takes is three things –

  1. Buyer’s age must be 21 years or older
  2. They shouldn’t have a criminal history
  3. They shouldn’t be mentally ill

Think about it… if the rules will be so simple, then why will there not be this gun culture.


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Having older sisters increases the chances of survival of baby elephants http://folderol.org/having-older-sisters-increases-the-chances-of-survival-of-baby-elephants/ http://folderol.org/having-older-sisters-increases-the-chances-of-survival-of-baby-elephants/#respond Tue, 21 Sep 2021 17:59:57 +0000 http://folderol.org/having-older-sisters-increases-the-chances-of-survival-of-baby-elephants/

September 21 (UPI) – Only children can be exposed to stigma, but for humans, growing up without siblings isn’t really dangerous. The same cannot be said of elephants.

According to a new study published on Tuesday in the Journal of Animal Ecology, young elephants that grow up with older siblings have higher survival rates and reproduce at a younger age than calves that grew up without siblings.

Females reared with older sisters had higher long-term survival rates and reproduced on average two years younger.

Elephants that start breeding earlier tend to generate more offspring in their lifetimes.

Male calves had slightly lower survival rates when raised alongside older sisters rather than older brothers. However, having older sisters was associated with higher body weight for male baby calves.

The researchers suggest that the phenomenon “live fast, die young” may explain the difference, as male elephants that mature faster can sacrifice their long-term health.

“Our research confirms that fraternal relationships shape the lives of individuals, particularly in social species, such as elephants, where cooperative behaviors are essential for the development, survival and reproductive potential of individuals,” said Vérane Berger , lead author of the study, researcher at the University of Turku. in Finland, said in a press release.

Studying wild elephants over long periods of time is quite difficult, making it almost impossible to study long-term behavior and health impacts of siblings.

For the latest study, the researchers studied semi-captive wood elephants living in Myanmar.

During the day, elephants are used as working animals. Local people ride the elephants and use the large mammal to pull plows and transport goods. At night, elephants live in the forest unsupervised.

Semi-captive elephants mate and interact with wild and tame elephants. The calves are raised by their mothers for five years until they are trained for the job by the local people.

Regulations established by the Myanmar Timber Enterprise limit the types and amount of work for which elephants can be deployed.

“Because elephants live in their natural habitats, there are many similarities to wild elephants, such as foraging for natural food and the lack of reproductive support,” said the study co-author, Mirkka Lahdenperä, in the press release.

“Although there are differences – in nature the family groups are probably larger – there are more similarities than differences and we could assume that some of the associations found in our study would also be true for wild elephants. But of course these should be studied, ”said Lahdenperä, postdoctoral researcher in the Elephant and Human Projects in Turku.

Researchers have studied the use of elephants for work in Myanmar for years, and records of wood elephant populations go back decades.

For the study, scientists analyzed information on the body mass, reproduction, sex and survival of 2,344 calves born between 1945 and 2018.

Because the researchers lacked information on the quality of maternal care and other external factors, they could not control for all of the variables that might influence survivability and sexual maturity.

“By collecting more information on mothers’ body mass at birth, we hope to disentangle the maternal effects from the effects on siblings,” Berger said.

“More data will also allow us to explore the effects of the environment on sibling relationships and to go into more detail on the effects siblings have on specific aspects of a young calf’s health,” such as immunity, muscle function, and hormonal variations, ”Berger said.


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Luis Miramontes helped activate the sexual revolution. Why is it not better known? http://folderol.org/luis-miramontes-helped-activate-the-sexual-revolution-why-is-it-not-better-known/ http://folderol.org/luis-miramontes-helped-activate-the-sexual-revolution-why-is-it-not-better-known/#respond Tue, 21 Sep 2021 14:00:00 +0000 http://folderol.org/luis-miramontes-helped-activate-the-sexual-revolution-why-is-it-not-better-known/

When Mexican scientist Luis Miramontes signed his lab notebook on October 15, 1951, he didn’t know he was documenting the story.

That day, he made a new molecule, norethindrone. Derived from the Mexican wild yam that locals call barbasco, norethindrone became one of the first active ingredients in birth control pills. “The Pill” put women in control of when to have children and allowed both men and women to enjoy sex without the possibility of reproduction, paving the way for radical social change.

The Miramontes notebook page has been immortalized in books and articles by his former supervisor, Carl Djerassi, as well as journalists. Yet compared to Djerassi and others who contributed to the pill, Miramontes has hardly been recognized, says Gabriela Soto Laveaga, historian of science at Harvard University and author of Jungle labs: Mexican peasants, national projects and pill making. “It is only recently that there has been even talk of Miramontes.”

In his lab notebook (illustrated), Luis Miramontes documented the final steps in the synthesis of norethindrone.L. Miramontes

Luis Ernesto Miramontes Cárdenas was born in 1925, the day after the Mexican Revolution. He grew up surrounded by strong female role models, including his aunt María Dolores Cárdenas Aréchiga, once a major in Pancho Villa’s army who later joined the army of teachers bringing education to the remotest corners of Mexico. The young Miramontes decided to pursue a career in the sciences. In the late 1940s, he was studying chemical engineering in Mexico City.

It was a good time and a good place to be a skilled molecule maker. Mexican company Syntex was exploding global competition in the production of low-cost hormones to treat disease. The reason was the Mexican yam, Dioscorea mexicana, which contained large amounts of a precursor that could be used to make several hormones. In 1949, Miramontes was part of a group of researchers assigned to Syntex projects under an agreement with the National Autonomous University of Mexico, or UNAM. Djerassi, an Austrian-born American chemist, “liked the way I worked,” Miramontes said in an interview in 2004. “If he wanted something to go right or be checked, he would give me the job.

Progesterone was just such a challenge. Doctors used it to prevent certain types of miscarriages and more, but it had to be injected to work. Djerassi and Syntex director George Rosenkranz wanted a progesterone pill. Following the lead of other scientists, Syntex made a modified progesterone derived from yam, designed to survive in the digestive tract and have more biological activity than progesterone. It was norethindrone. Miramontes took the final step of their recipe, adding a crucial carbon-carbon triple bond.

Meanwhile, experts and activists have made the connection between progesterone and birth control because progesterone prevents ovulation during pregnancy. This paved the way for the use of norethindrone in contraception.

chemical structures of norethindrone and norethynodrel
After Luis Miramontes developed norethindrone (left), chemists at a rival company reported norethynodrel (right), a similar compound chosen for use in the first birth control pill.PubChem

However, this did not end up in the first pill. A year after Syntex reported norethynodrone, chemists at rival company Searle, an American company, reported their own compound, norethynodrel. It differed from norethindrone by the position of a single carbon-carbon double bond, and the addition of stomach acid converted it to norethindrone. Gregory Pincus, a developer of the first pill, chose Searle’s compound. But norethindrone had a longer lasting impact. Searle’s compound is no longer marketed. As of 2018, norethindrone was still the 138th most prescribed drug in the United States.

Why, then, has Miramontes remained an obscure figure? He was a student at a time when science was particularly hierarchical. And the fact that Searle beat Syntex to market cut Mexico – and Miramontes – from the narrative. Fame may not have been Miramontes’ preference. His son Octavio Miramontes Vidal says: “My father was a calm individual. He was not someone who sought fame. On the other hand, Djerassi “did not aspire to modesty”, according to an obituary.

Miramontes Vidal says his father was bilingual, but Miramontes did not choose to write his story in English. Others did: Pincus mentioned Syntex in the acknowledgments for his book, but not his chemists. Djerassi credited Miramontes in his works, but called Miramontes “a young Mexican chemist” when he himself was less than two years older. “It’s about who controls the narrative, and the person who controls the narrative of the invention of the pill in the United States becomes in many ways Djerassi,” says Soto Laveaga.

Miramontes ended up accepting a managerial position at Searle to earn more money to support his growing family; he and his wife had 10 children. From there, the university seemed to close its doors, says his son Miramontes Vidal, who is a physicist at UNAM. Although he fulfilled all the requirements, Miramontes never obtained a doctorate. He was not a member of the Mexican Academy of Sciences, co-founded by one of his mentors at UNAM.

The parish priest of Miramontes threatened his wife with excommunication, says Miramontes Vidal – the influence of the Catholic Church in 1960s Mexico cannot be overstated. Miramontes may have alluded to this when he wrote that the Pill “has generated deep and serious moral questions in some sectors of society and reactionary obtuse attitudes in others.”

Luis Miramontes alongside George Rosenkranz
Luis Miramontes (left) reunites with George Rosenkranz at the National Autonomous University of Mexico during a celebration of the 50th anniversary of norethindrone synthesis in 2001.Courtesy of the Miramontes-Vidal family, official archives, Institute of Physics of the National Autonomous University of Mexico

The times have changed. In the 1980s, Miramontes won awards from the Mexican state governments and the Mexican Chemical Society. In 2010, the president of the Mexican Academy of Sciences ranked Miramontes’ work among Mexico’s top three scientific contributions. But the damage was done. Miramontes Vidal says that when his father died in 2004, the newspapers did not know who he was. News of his death traveled so slowly that it took the American Chemical Society two years to publish an obituary.

Miramontes’ own writings suggest satisfaction with his heritage. “I consider myself lucky”, he wrote in 2001, “because the researcher, in his zeal to discover the truth at the beginning of his work, does not often realize what he is going to find. “


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Competitor in the manufacture of viral vectors and plasmid DNA http://folderol.org/competitor-in-the-manufacture-of-viral-vectors-and-plasmid-dna/ http://folderol.org/competitor-in-the-manufacture-of-viral-vectors-and-plasmid-dna/#respond Tue, 21 Sep 2021 13:17:46 +0000 http://folderol.org/competitor-in-the-manufacture-of-viral-vectors-and-plasmid-dna/

New York, September 21, 2021 (GLOBE NEWSWIRE) – Reportlinker.com announces the publication of the report “Viral Vector & Plasmid DNA Manufacturing Competitor Analysis Report – Global Forecast to 2026” – https://www.reportlinker.com/ p06149108 /? utm_source = GNW
05% to reach $ 2,632.73 million by 2026.

FPNV positioning matrix:
FPNV Positioning Matrix assesses and ranks vendors in the viral vector and plasmid DNA manufacturing market based on business strategy (company growth, industry coverage, financial viability, and channel support) and product satisfaction (value for money, ease of use, product features), and customer support) which helps businesses make better decisions and better understand the competitive landscape.

“Spark Therapeutics Inc. achieved the highest score as a leading supplier on FPNV positioning matrix for the viral vector and plasmid DNA manufacturing market.”

Forefront is highly rated by users for product satisfaction and has substantially good business strategy scores. F-Forefront includes Spark Therapeutics Inc., Lonza Group AG, Merck KGaA and c-LEcta GmbH.

“Sirion-Biotech GmbH has achieved the highest score as a scout and is expected to be at the forefront over the next two years”

Pathfinder has significant product satisfaction ratings, but somehow lacks a business strategy when it comes to avant-garde and vital elements. P-Pathfinder includes Sirion-Biotech GmbH, Cobra Biologics Limited, BioNTech IMFS GmbH, Novasep Inc., Creative Biogene, Genezen Laboratories, Kaneka Eurogentec SA, Cevec Pharmaceuticals GmbH, Cell and Gene Therapy Catapult, Vigene Biosciences, Inc. and uniQure NV.

“Wuxi AppTec Co., Ltd. named as the next supplier to watch in the viral vector and plasmid DNA manufacturing market ”

Niche solutions meet the needs of a relatively smaller segment of the overall market. They don’t have Forefront’s business strategy. They may have been assessed positively on product satisfaction but have not yet received enough reviews to validate them. N-Niche includes Wuxi AppTec Co., Ltd., Biovian Oy, Batavia Biosciences BV, GeneOne Life Science, Inc., ABL Inc. and FinVector Vision Therapies.

“FUJIFILM Diosynth Biotechnologies Inc.’s innovative offerings are expected to increase the level of product satisfaction for the viral vector and plasmid DNA manufacturing market over the coming years”

Vital has a relatively good business strategy but has yet to hit Forefront’s business strategy. However, they have a low rate of product satisfaction. V-Vital includes FUJIFILM Diosynth Biotechnologies Inc., Thermo Fisher Scientific Inc., GE Healthcare, and Miltenyi Biotec GmbH.

Market share analysis:
The market share analysis offers the analysis of the suppliers considering their contribution to the overall market. It provides the idea of ​​its revenue generation in the overall market compared to other space providers. It provides insight into the performance of vendors in terms of revenue generation and customer base compared to others. Knowing the market share gives an idea of ​​the size and competitiveness of the suppliers for the base year. It reveals the characteristics of the market in terms of traits of accumulation, fragmentation, dominance and fusion.

Competitive scenario:
The competitive scenario provides a outlook analysis of the various business growth strategies adopted by the vendors. The news covered in this section delivers valuable insights at different stages while staying up to date with the business and engaging stakeholders in the economic debate. The competitive scenario represents press releases or news from companies categorized as M&A, Agreement, Collaboration and Partnership, New Product Launch and Improvement, Investment and Funding, and Reward, Recognition and Expansion. All the information gathered helps the supplier to understand the market gaps and the strengths and weaknesses of the competitors, thus providing information to improve products and services.

Company usability profiles:
The report deeply explores the significant recent developments of leading vendors and innovation profiles in the global viral vector and plasmid DNA manufacturing market including ABL Inc., Batavia Biosciences BV, BioNTech IMFS GmbH, Biovian Oy, c -LEcta GmbH, Cell and Gene Therapy Catapult, Cevec Pharmaceuticals GmbH, Cobra Biologics Limited, Creative Biogene, FinVector Vision Therapies, FUJIFILM Diosynth Biotechnologies Inc., GE Healthcare, GeneOne Life Science, Inc., Genezen Laboratories, Kaneka Eurogentec SA, Lonza Group AG, Merck KGaA, Miltenyi Biotec GmbH, Novasep Inc., Sirion-Biotech GmbH, Spark Therapeutics Inc., Thermo Fisher Scientific Inc., uniQure NV, Vigene Biosciences, Inc. and Wuxi AppTec Co., Ltd.
Read the full report: https://www.reportlinker.com/p06149108/?utm_source=GNW

About Reportlinker
ReportLinker is an award winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need – instantly, in one place.

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]]> http://folderol.org/competitor-in-the-manufacture-of-viral-vectors-and-plasmid-dna/feed/ 0 DNA test sentences man to 10 years in prison for raping his underage daughter; 2 released | Nagpur News http://folderol.org/dna-test-sentences-man-to-10-years-in-prison-for-raping-his-underage-daughter-2-released-nagpur-news/ http://folderol.org/dna-test-sentences-man-to-10-years-in-prison-for-raping-his-underage-daughter-2-released-nagpur-news/#respond Tue, 21 Sep 2021 00:15:00 +0000 http://folderol.org/dna-test-sentences-man-to-10-years-in-prison-for-raping-his-underage-daughter-2-released-nagpur-news/ Nagpur: District and Extra Sessions Judge SM Ali on Monday sentenced a man in his 40s to 10 years rigorous imprisonment and a fine of 10,000 rupees after convicting him of raping his underage daughter 14 years old. The girl had given birth to a baby in 2017.
A DNA test had established the paternity of the father, after the girl refused to reveal the baby’s father. The test also led to the acquittal of two other defendants. The rape survivor was the daughter of his first wife’s rapist.
The court convicted the man under the provisions of section 376 and its subclauses of the Indian Penal Code as well as the Protection of Children from Sexual Offenses Act 2012.
It was learned that the survivor named two neighbors as the perpetrators and that they were arrested in the case, which rose to prominence after the minor was diagnosed five months pregnant. She had subsequently given birth to a baby as well.
The minor named her father the rapist after the baby’s DNA test failed to match samples from the two previous defendants. After his father’s DNA test correspondence, he was taken into custody by the Pachpaoli police who had registered the case in July 2017. The case was investigated by the sub-inspector. from the time of the Pachpaoli police station, Mangala Mokashe.
Additional prosecutor Asavari Parsodkar said 14 witnesses had been interviewed, but the testimony of the minor victim and chemical analysts were crucial to the conviction.
The case had already been handled by the additional PP Rashmi Khaparde.


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bne IntelliNews – Georgia inundated with leaked clergy surveillance tapes http://folderol.org/bne-intellinews-georgia-inundated-with-leaked-clergy-surveillance-tapes/ http://folderol.org/bne-intellinews-georgia-inundated-with-leaked-clergy-surveillance-tapes/#respond Mon, 20 Sep 2021 23:43:34 +0000 http://folderol.org/bne-intellinews-georgia-inundated-with-leaked-clergy-surveillance-tapes/

An anonymous leak of thousands of intercepted phone calls – and in some cases one-on-one conversations – targeting Georgian clergy rocked the country just ahead of crucial elections.

On September 13, an anonymous source sent emails and messages to dozens of reporters, sending a link to a website containing files of transcripts of conversations recorded by the State Security Service (SSS). The records indicated that the service had long snooped on the conversations of religious leaders with journalists, diplomats and each other, and created files on relatives, friends, doctors and lawyers of clergy.

“There is no such thing as a more diabolical and terrible job than the one in which I have spent several years! the home page of the read site. “This title is not like that – the title is noble – the state security service. […] In reality, nothing poses as much of a threat to our state, nothing rots it like us! We are cancer and I am one of the metastases!

The website has since disappeared, but the reporters who downloaded the files have combed them through. It is not known exactly how true the information is, but numerous surveillance targets have confirmed the authenticity of the files about them.

Through files

One of the files, titled “Adulteurs”, lists the names, identification numbers, addresses and photos of priests and nuns who have allegedly had relations with each other. Some files alluded to the “kompromat” video – Video

Some media also reported that some of the files referred to priests’ sexual relations with underage girls and boys.

Other files claim to identify dozens of priests of “non-traditional sexual orientation” as well as drug addicts, one of whom is said to have “systematically” used drugs in his own church.

The allegations have already caused tensions within the church: local media have captured a confrontation between the clergy of Chkondidi, in western Georgia, where priests physically assaulted the metropolitan of the diocese, calling him “adultery” and “liar”.

Many files include conversations with diplomats, including the ambassadors of the United States, the European Union and Israel. Most were conversations with members of the clergy, but some were internal communications.

“EU Ambassador to Georgia Carl Hartzell spoke with his assistant – and told him that tomorrow, October 9 at 11:00 am, the scheduled meeting with the priests of the ‘St. Andrew the First-Called University of the Patriarchate will last about an hour and a half,’ read one of the files, reported the local news channel Formula TV.

“The eavesdropping of diplomatic missions, even if they are not directed against them, constitutes a violation of the Vienna Convention on Diplomatic Relations”, declared Hubert Knirsch, the German ambassador to Georgia, who was mentioned several times in the files, in a maintenance with the Netgazeti information site.

This reporter even made a small appearance in the leaks. They contain a transcript of a conversation I had in May 2020 with Bishop Rusudan Gotsiridze of the Evangelical Baptist Church for a story I was working on for another media about the church’s offer to host those suffering as a result of the COVID pandemic; they even explicitly mentioned wanting to welcome transgender people.

“On May 5, Rusudan Gotsiridze, bishop of the Evangelical Baptist Church, told RFE / RL reporter Tornike Mandaria that Bishop Malkhaz Songhulashvili’s initiative to offer shelter did not receive many responses. for now, ”one of the transcripts, recorded by an intelligence officer named Akaki Nemsadze, reads. “T. Mandaria asked R. Gotsiridze to contact him in case any requests appear related to this initiative in order to prepare an article on this subject.

While the files appear to document numerous criminal acts, none of the priests named had been arrested.

The floor announcement on September 14, she opened an investigation for “breach of confidentiality of communication”.

Repeated offenders

Modern Georgia has a long story politically motivated surveillance. The previous government, led by the United National Movement (UNM) party, was known for the practice and when the current regime, led by the Georgian Dream Party, came to power, it vowed to stop it.

In 2013, the authorities publicly shredded 100 CDs, which they claimed contained personal recordings which they had inherited.

Human rights defenders began pushing for stronger safeguards against surveillance abuse, and in 2016 the Constitutional Court declared regulations unconstitutional that allowed the SSS to eavesdrop on personal conversations through direct access to servers. mobile phone operators.

The court ruled that the “key to the black box” should not be in the hands of law enforcement investigators.

Nonetheless, in 2017 a dreamy Georgian-majority parliament passed a law giving this key to a new agency under the SSS, although it also required court permission for such access.

The message from government officials changed several times in the days following the leak. They initially accused the UNM of attacking the state and the Church. Mamuka Mdinaradze, the ruling party faction leader in parliament, claims “They recorded it themselves, they edited it themselves, they confirmed it themselves.”

Then Prime Minister Irakli Garibashvili pointed the finger at his predecessor Giorgi Gakharia – who has since has established itself as a political competitor– claiming that he and his team had “access to very large amounts of information, including the surveillance service” and that the authorities were investigating these links.

Gakharia has denied knowing about mass surveillance in the SSS during his tenure as prime minister, and before that as interior minister.

Church leaders said they believed the leak was aimed at influencing the crucial local elections coming up on October 2, but did not say how.

“There is an increasingly clear impression that the forces allegedly involved in disclosing the details of the surveillance are attempting to manipulate the elections using the church,” the Patriarchate spokeswoman told reporters. church, Andria Jagmaidze.

The SSS, for its part, called on the media to refrain from disseminating “inaccurate and unverified” information until the end of its investigation.

“Reproduction of such information violates the dignity of individuals, security guards and the service as a whole,” the SSS said in a statement. “It undermines confidence in law enforcement and seriously damages the state security system. “

Tornike Mandaria is a journalist based in Tbilisi.

This article originally appeared on Eurasianet here.


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How did Yorick survive the virus in the comics? http://folderol.org/how-did-yorick-survive-the-virus-in-the-comics/ http://folderol.org/how-did-yorick-survive-the-virus-in-the-comics/#respond Mon, 20 Sep 2021 16:03:14 +0000 http://folderol.org/how-did-yorick-survive-the-virus-in-the-comics/

Before Y the Last Man was a live-action series, the comic revealed the disgusting way Yorick Brown survived the series’ plague extinction event.

With Y: The Last Man finally making his long-awaited live-action debut, the question of how Yorick Brown survived the “gendercide” that wiped out anyone with a Y chromosome has once again arisen. The series didn’t really detail the plague. as much as it focuses on world-building and emotional issues with the characters, but the completed Vertigo Comics series has spent considerable time on this particular topic, offering a potential solution to why Yorick was able to survive.

In Brian K. Vaughan and Pia Guerra’s comic book series, an unknown event wiped out (almost) all mammals with a Y chromosome, causing them to bleed from their heads and die, except for the artist from escape Yorick and his pet monkey Ampersand. But as the last of its kind, it was in danger as a resource to be experienced, potentially playing a crucial role in the long-term survival of humanity. His journey would then take him to his mother, Jennifer, who used her political influence, along with Agent 355, to bring him to Dr. Allison Man’s lab where they uncovered a dirty and disgusting secret about his survival.


RELATED: Y: The Last Man: What Really Killed The Men In The Comics?

Allison studied both Yorick and Esperluette and determined that it was not luck or divine providence. Y: The last man # 30 made him think the capuchin throwing poo at Yorick produced a science shield. Somehow, Yorick’s body had a reaction and developed unique antibodies, which she said provided immunity. Yorick couldn’t believe it, but later when Allison met her father, Matsumori, it became clear that this was not a random mutation in the animal.

Her father hated the way she competed with him in cloning experiments and imprinted. As such, he used monkeys as laboratory rats, infecting them with chemical agents. One of them was Ampersand, whom he sent to Allison to kill his unborn clone, only for the animal to meet up with Yorick, who was looking for something to train. Matsumori believed that when Allison went into labor it meant that sexual reproduction was no longer necessary, which prompted Earth to send out a bio-wave to kill men. However, it seems that the chemicals in the ampersand had the opposite effect, as the science of these doctors was accurate, thus saving him from the signal of death. In Yorick’s case, he was biologically contaminated with monkey poo, which is why he could resist it.

RELATED: How Y: The Last Man Will Differ From The Comics

Ironically, Yorick hated being in close contact with all of Ampersand’s raw bodily fluids, and he couldn’t believe that they had spared them from the doomsday event. Of course, the exact cause of the outbreak has never been confirmed, as Vaughn himself teased many different angles on the incident.

However, Ampersand’s poo theory is science-based and seems more plausible than the theory that the engagement ring Yorick bought from a magical ship for Beth saved him from whatever was going on. Seeing that the ring does not explain Ampersand’s survival, it leaves the poo evidence more solid as the Capuchin also threw it at Matsumori, which suggests the medic survived as he was also protected like Yorick.

KEEP READING: Y: The Last Man: Yorick Brown Is The Most Cursed Hero Of His Apocalypse

Did DC Nearly Kill Swamp Thing’s Wife and Daughter?


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Recombinant DNA Technology Market Size, Analysis & Key Manufacturers – Novo Nordisk A / S, Sanofi, Eli Lilly & Company, Amgen Inc, Profacgen, Genscript, Novartis AG http://folderol.org/recombinant-dna-technology-market-size-analysis-key-manufacturers-novo-nordisk-a-s-sanofi-eli-lilly-company-amgen-inc-profacgen-genscript-novartis-ag/ http://folderol.org/recombinant-dna-technology-market-size-analysis-key-manufacturers-novo-nordisk-a-s-sanofi-eli-lilly-company-amgen-inc-profacgen-genscript-novartis-ag/#respond Mon, 20 Sep 2021 13:24:25 +0000 http://folderol.org/recombinant-dna-technology-market-size-analysis-key-manufacturers-novo-nordisk-a-s-sanofi-eli-lilly-company-amgen-inc-profacgen-genscript-novartis-ag/

New Jersey, United States, – The Recombinant DNA Technology Market The research report offers the key analysis of the Recombinant DNA Technology market situation including the best facts and data, definitions, SWOT analysis, expert opinions, and the latest global developments. The report also calculated the market size, revenue, price, revenue, gross profit margin and market share, cost structure and growth rate. The report will help stakeholders understand the competitive landscape and better understand their business.

The Recombinant DNA Technology market was valued at USD 108.3 billion in 2020 and is expected to reach USD 127.3 billion by 2028, with a CAGR of 7.31% from 2021 to 2028.

In addition, a compelling Recombinant DNA Technology market report presents key data, current market trends, market environment, technological innovations, upcoming technologies, and technological advancements in related industries. When describing the strategies for producing, marketing, selling, promoting and distributing products and services, all of this data and information is very remarkable for business. This market research report should be used to gain valuable insight into the market in a cost effective manner. Universal Recombinant DNA Technology report is created with all the business requirements critical for the successful growth of the company in mind.

The report has conducted extensive research on the market segments and sub-segments and clarified which market segment will dominate the market during the forecast period. To assist clients in making informed decisions on business investment plans and strategies in the Recombinant DNA Technology market, the report involves in-depth information regarding regional market performance and competitive analysis.

The report covers an in-depth analysis of the major market players in the market, along with their business overview, expansion plans, and strategies. The major players studied in the report include:

Novo Nordisk A / S, Eli Lilly & Company, Sanofi, Amgen Inc, Profacgen, Genscript, Novartis AG, Pfizer Inc, Merck & Co, Cibus.

Recombinant DNA Technology Market Segmentation

Recombinant DNA Technology Market, By Product

• Medical
• Non-medical

Recombinant DNA Technology Market, By Component

• Expression system
• Cloning vector

Recombinant DNA Technology Market, By Application

• Food and agriculture
• Health and disease
• Environment
• Others

Scope of Recombinant DNA Technology Market Report

Report attribute Details
Market size available for years 2021 – 2028
Reference year considered 2021
Historical data 2015 – 2020
Forecast period 2021 – 2028
Quantitative units Revenue in millions of USD and CAGR from 2021 to 2028
Covered segments Types, applications, end users, etc.
Cover of the report Revenue forecast, company ranking, competitive landscape, growth factors and trends
Regional scope North America, Europe, Asia-Pacific, Latin America, Middle East and Africa
Scope of customization Free customization of the report (equivalent to up to 8 working days for analysts) with purchase. Add or change the scope of country, region and segment.
Price and purchase options Take advantage of personalized shopping options to meet your exact research needs. Explore purchasing options

Geographic segment covered in the report:

The Recombinant DNA Technology report provides information about the market area, which is further subdivided into sub-regions and countries / regions. In addition to the market share in each country and sub-region, this chapter of this report also contains information on profit opportunities. This chapter of the report mentions the market share and growth rate of each region, country and sub-region during the estimated period.

  • The Middle East and Africa (GCC countries and Egypt)
  • North America (United States, Mexico and Canada)
  • South America (Brazil etc …)
  • Europe (Turkey, Germany, Russia UK, Italy, France, etc.)
  • Asia Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia and Australia)

Key questions answered in the report:

  • Who are the main global players in this recombinant DNA technology market?
  • What is their company profile, their product information, their contact details?
  • What was the global market status of the market?
  • What was the capacity, production value, cost and profit of the market?
  • What are the projections of the global industry taking into account the capacity, output and production value?
  • What will the cost and profit estimate be?
  • What will be the market share, supply and consumption?
  • What is the market chain analysis by upstream commodity and downstream industry?
  • What are the market dynamics of the market?
  • What are the challenges and opportunities?
  • What should be the entry strategies, the countermeasures to the economic impact, the marketing channels for the industry?

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